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Emblem of United Earth Starfleet Command, including UESPA's name
The United Earth Space Probe Agency (abbreviated UESPA) was an organization controlled by the United Earth responsible for space exploration.
UESPA evolved, in part, from the United Earth AeroNav Forces of the early 21st century. (TOS novel: Strangers from the Sky)
In 2067, the agency launched the Friendship One probe toward the Delta Quadrant, as part of a series of unmanned exploration. (VOY episode: "Friendship One")
By the 2130s the United Earth Starfleet had taken UESPA's place as Earth's leading exploratory agency, but the two would continue to cooperate. (ENT episode: "First Flight")
UESPA personnel would also aid in the construction of the Enterprise (NX-01) in 2150. (Star Trek: Enterprise)
UESPA would continue to help control Starfleet vessels into the 2260s. James T. Kirk would report the destruction of the USS Antares to UESPA. Kirk would also inform John Christopher that UESPA was the USS Enterprise's operating authority. (TOS episodes: "Charlie X", "Tomorrow is Yesterday")
In one alternate timeline the IKS Qu' was a UESPA vessel prior to capture by Klingons. (TNG novel: Q & A)
In another alternate universe, UESPA became a purely military organization after several other powers established the Interstellar Coalition. They also operated the UESS Enterprise in the 2260s. (Star Trek: Myriad Universes novel: A Less Perfect Union)
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