Reed Richards of Earth-616 was cast into the Negative Zone by the Brute (his evil twin). With Annihilus's help, they thwarted the Mad Thinker and the Brute.
The first human to encounter the Tyannans was the Brute. He took advantage of their trust and, with their unwitting help, built a device to control their minds. He followed that with a device to take them all back out of the black hole, so that he could conquer the Negative Zone and then the Marvel Universe. Activating that device attracted the attention of Annihilus, Blastaar, and the Fantastic Four, who investigated and stopped the Brute's plans. Freed from their thralldom, the Tyannans went back to their realm and erected an impregnable barrier.[1]
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