The first iteration of a Red Squadron was equipped with Aurek tactical strikefighters fought with Admiral Forn Dodonna's fleet at the Battle of Rakata Prime, which was the climactic battle of the Jedi Civil War. During the confrontation, the squadron reinforced the breach in the Sith lines formed by Green Squadron, further paving the way for Dodonna's capital ships to assault the Star Forge.
Just prior to the Clone Wars, Red Squadron was a Jedi squadron that flew early versions of Jedi starfighters, likely predecessors to the Delta-6 starfighter. Red Squadron saw action during the Stark Hyperspace War, where it accompanied fellow Jedi from Blue Squadron into battle against the Stark Commercial Combine at the Fifth Battle of Qotile. Both squadrons were led by the ace pilot, Jedi Master Saesee Tiin.
At the beginning of the Clone Wars, Red Squadron was piloted exclusively by Jedi flying Delta-7 Aethersprite-class light interceptors, a new experimental craft that was built specifically for Jedi. It was commanded by Jedi General Tsui Choi, with his support, Aayla Secura. They led their squad against incoming droid starfighters at the Battle of Kamino, and took full command over the air battle when Blue Leader, General Kenobi, was shot down over the ocean.
In the second year of the conflict, Red Squadron was under the command of Jedi Master Plo Koon. The Kel Dorian Master once led his fighters into battle against pirate ships attacking a diplomatic cruiser carrying Senator Bail Organa. At this point, Red Squadron was a mix of Delta-7s flown by Jedi and V-19 Torrent starfighters flown by clone pilots.
Later, during the Clone Wars, Red Squadron fought in the Battle of Muunilinst, under the command of Anakin Skywalker. During the battle, Skywalker ordered Red Squadron to fire its arsenal of missiles across the bow of Cruiser 8, whereupon he led a wing of Nantex starfighters into the line of fire. At first Red Leader questioned the order telling him that there were no targets, until Anakin gave the order again. The campaign was ultimately successful for the Republic forces.
Along with the complement of V-19 Torrents, Red Squadron also was at some point outfitted with BTL-B Y-wing starfighters. The ships were made available to the Republic forces after they were field tested by Shadow Squadron near the Kaliida Nebula against the Malevolence. Red Squadron was outfitted with a flight of them bearing red markings, thereby augmenting the V-19s that they fielded.
After the development of the ARC-170 starfighter, Red Squadron was among the units in the Republic fleet to receive ARC-170s for combat. Red Squadron piloting these new ships preferred their craft to be balanced more in favor of shields than firepower when compared to their comrades in Blue Squadron, making them valuable for penetration runs.
General Kenobi, ultimately took command of Red Squadron during the last year of the war. Now part of the Open Circle Fleet, Red Squadron was comprised of Eta-2 interceptors, ARC-170 starfighters and V-wing starfighters.
During the Third Battle of Tythe, Anakin Skywalker and Obi-Wan Kenobi led Red Squadron through the Separatist fleet on a mission to capture Count Dooku alive. Initially managing to destroy a Techno Union battle cruiser on the way, the squadron, nonetheless, was destroyed by defending Hailfire droids, STAPs, and battle droids once they reached the lower atmosphere of Tythe.