From The Vault

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Plasma Grenades are explosive thrown weapons in Fallout , Fallout 2, Fallout 3, and Fallout Tactics.

Fallout and Fallout 2

Fallout/Fallout 2 weapon Grenade (Plasma) damage: 40 - 90 damage type: Plasma attack modes: Throw (AP: 4, R: 15) min. Strength: 4 hands req.: 1 weight: 1 pound value: $300 prototype id: 26

Plasma 'nades are very rare in Fallout, but show up quite a bit in Fallout 2. They are mainly used by the Hubologists and Mercenaries in random encounters, but also by the Enclave as well. Not recommended to use them against the Enclave soldiers as their Advanced Power Armor can absorb around 50-80% damage. However, just about everyone and everything else has a low plasma resistance, making this grenade type the most useful late to end game.

Fallout 3

Fallout 3 weapon Plasma Grenade Attack statistics dmg/attack: 1 + 150 (240) related perks: Demolition Expert (+ 90 ) Criticals crit dmg: 0 crit chance: x 1 Other skill: Explosives AP: 24 item HP: 5 weight: 0.5 value: 50 base id: 00004332 The blast of a Plasma Grenade

The Plasma Grenade is a magnetically-sealed plasma delivery unit, with detonating explosives, creating a fiery blast of green superheated plasma on detonation, with a high chance to cripple limbs. A critical hit will reduce the target to green goo. It seems to have the same blast radius as its less powerful variant, the Frag Grenade. They are only used by Enclave Officers and Smugglers, introduced in the Point Lookout add-on.

It is also possible to plant a live grenade on an NPC by passing one from your inventory to the NPC's inventory via pickpocketing. This will kill the NPC, regardless of how much health he has, but far more common grenades such as the Frag Grenade can do this too.

Fallout Tactics

Fallout Tactics weapon Grenade (Plasma) damage: 40 - 90 damage type: Plasma attack modes: Throw (AP: 6, R: 15) min. Strength: 4 hands req.: 1 weight: 1 lbs. value: N/A

	The following is based on Fallout Tactics and some details might contradict canon.

End-game weapon of a grenadier, plasma grenades deliver a good all-around punch and is abundant enough to make using it feasible as a main weapon in the last few missions. However, its value is somewhat detracted by the fact that end-game revolves around fighting robotic forces, which are prime targets for Pulse Grenade. Thus, it's best to use plasma grenades as soon as they become available, and don't attempt to conserve them.