After events which parallel that of Mary Shelley's novel, Frankenstein; or, The Modern Prometheus, Frankenstein's Creature was assumed dead in Europe when he sank beneath the ice. However, he survived and swam to America, having 'many adventures'. In 1870, he fought Melmoth, the Ringmaster of the Circus of Maggots, and stopped him from destroying a town with maggot-hominids. Exhausted, he sank into the ground.
In 2005, a high school student, called 'Uglyhead' by all the other children, acquires telepathic abilities, which he uses to torment his peers. At the senior prom, the now-docile students are killed by the Sheeda maggot-hominids. This causes the return of Frankenstein, who makes short work of the maggots and the boy, before burning down the school to cover the bodies. Afterwards, Frankenstein makes his way to Mars through an Erdel Gate, where he confronts Melmoth once again. Frankenstein frees the children Melmoth has enslaved to work in his gold mines, and feeds Melmoth to the flesh-eating, praying mantis-like horses of Mars. Yet before he is consumed, Melmoth reveals that it was not lightning that brought the monster to life, but several drops of his own immortal blood, sold to Frankenstein's creator, that still course through Frankenstein's veins.
Soon afterwards, Frankenstein meets an old acquaintance greatly resembling the "Bride" in James Whale's Bride of Frankenstein, albeit with four arms. She is now an agent of the Super Human Advanced Defense Executive (S.H.A.D.E.), a secret government agency that temporarily drafts Frankenstein as well. Of their previous relationship, she says, "It's nothing personal, but you were never my type."
Under the employ of S.H.A.D.E., he stows away on a time-ship which brings him to the Sheeda realm in the distant future. There, he destroys their world-destroying fleet, kills the Sheeda-Queen's time-yacht's steersman, and hijacks her ship to the present. Once in the present, though, Klarion gains control of Frankenstein using a witch-brand and forces him to take the castle back to the future.
A individual called Young Frankenstein has appeared in Teen Titans as a member of the team during the "Lost Year". Young Frankenstein was apparently killed by Black Adam during WWIII, but was shown to survive during the run-up to Final Crisis.Frankenstein is currently a senior field agent S.H.A.D.E. He was present for the raid on the Dark Side Club.
Frankenstein has a weakness to the witch-brands used by the residents of Limbo Town. As an undead, he may also have a few adverse reactions to intense ambient heat in his environment.
Frankenstein is armed with a three-foot-long sword, which he claims once belonged to the Archangel Michael, and a large antique pistol, which he calls his 'steam-gun'.