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Earth-2149 was largely identical to that of the main Marvel reality, Earth-616, with only a few minor differences. For example, Colonel America was at one point President of the United States, though he never served a full term, and some characters, such as Luke Cage and Falcon (Sam Wilson) retained older versions of their costumes. This reality was ravaged when a version of the Sentry literally punched his way in from yet another alternative world, bringing with him a disease that turned individuals into flesh-eating zombies. The Avengers were the first on the scene after Sentry crashed in the middle of Manhattan, and all were quickly killed or infected. The disease soon spread throughout the superhuman community, with the super powered undead feasting on the non-powered population. With most of the human life of this Earth extinguished, the super-zombies wandered the world, tormented by hunger but with nothing to eat.
The zombie contagion passed via a bite from an infected being. The infected appeared to be dead, or at least decaying, but retained their intelligence, personality and special abilities. The disease caused a hunger in the host, a hunger which could only be sated by ingesting the flesh of the living; the flesh of other infected tasted foul to them and could cause them to be ill. The hunger affected the infected's self control; the more hungry they were, the less rational and intelligent they became. Once sated, the zombies' personalities re-emerged, and the more humane and moral individuals often felt great guilt at this point.
There was no known cure for the disease, and it appeared to be 100% infectious; both Wolverine and the Hulk, individuals normally highly resistant or immune to diseases, were affected. However, as noted by Spider-Man, those with any kind of accelerated healing appear to be able to fend off the zonbification longer after being bit than others, however the virus eventually takes hold of him. The disease was also shown to affect Asgardians.
The contagion appeared to have an addiction element to it, as it seemed if a victim could be isolated from a food supply, within a couple of weeks the cravings disappeared and the subject was able perform a functioning role within society, albeit with necrotised flesh, and near-immortality.
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