Earth begins to be abandoned by the rich and powerful as the sun goes nova.
Those left behind have fractured into millions of nation-states ("Alliances") battling through the ether in the Transmat Wars. (DWM: The Keep).
At around this time, humanity first begins to develop time travel. The Supreme Alliance, at the initiative of its minister of justice Magnus Greel, experiments with time travel using a method based on Double nexus particles and zygma beam, but this proves to be a dead end. Magnus Greel was said to be the first human to travel trough time, but became horribly disfigured for it. (DW: The Talons of Weng-Chiang)
Early 51st century - Magnus Greel kills approximately 100,000--a deed that earns him the epithet "Butcher of Brisbane".
Late 51st century - The Time Agency formed and began employing Time Agents for missions in other time periods. (DW: The Empty Child) Later it was closed down and only seven agents were left. (TW: Kiss Kiss, Bang Bang)
Unknown - The Doctor and Donna Noble visit The Library where they face an infestation by the Vashta Nerada, and the Doctor meets River Song for the first time in his personal timeline (but not in hers). The nature of The Library is revealed as the Doctor retrieves the consciousnesses of some 4,022 humans who were uploaded to the memory banks of the supercomputer, CAL. (DW: Silence in the Library / Forest of the Dead)
River Song is working in this century, and ultimately ends up preserved in the CAL computer during this time, but given her travels with the Doctor it's uncertain if she was actually a native of the century. K9 is a resident of this century but was created in the previous.